Can Medicines Cause Kidney Stones? – Causes & Symptoms

We’ve all heard someone or the other complaining about the pain of their kidney stones, or in the worst case, you might be one such person who knows the pain from suffering from these stones yourself. But what are they? How are they formed? What are the causes, symptoms? We often don’t know.

Kidney stones are hard and small deposit formations that are often painful. These deposits are made up of acid salts and minerals that accumulate together inside the kidneys. They are usually known to cause permanent damage. 

Does Kidney Stone Leads To Kidney Failure ?

It does not usually cause symptoms until it starts moving. If it clogs up the uterus, it can block the urine flow which makes the kidneys, which can be painful. 

Symptoms of kidney stone may include :

  • Brown, red or pink urine
  • Severe pain in sides and back
  • Burning sensation while urinating
  • Urine that smells bad
  • Fluctuating pain
  • Vomiting and nausea
  • Fever and chills if infected
Does Kidney Stone Leads To Kidney Failure

Kidney stones usually do not have any causes. There are a number of reasons that increase vulnerability. When urine contains more amount of oxalate, calcium, and uric acid, kidney stones are formed. To understand the cause, it becomes necessary to know the type of kidney stone you have.

When we talk about the causes of kidney stones, many people wonder if medications cause kidney stones. It may seem a little rare, but it is likely. Medications can induce kidney stones. 

There are many medications used to treat a variety of conditions, which paves the way to stone formation in kidneys. Drugs that induce kidney formation include carbonic anhydrase inhibitors, loop diuretics, and laxatives when abused. When drugs crystallize the stone components, kidney stones can be induced. 

  • Loop Diuretics

Loop diuretics, inclusive of bumetanide and furosemide, inhibit each sodium and calcium resorption inside the thick ascending limb of the loop of Henle. Similarly to exerting a diuretic effect, this mechanism of motion produces a hypercalciuric kingdom. Renal calculi have been mentioned in as much as 64% of low-delivery-weight infants receiving furosemide remedy. Furthermore, the hypercalciuric effect of furosemide in infants is more desirable by using a reduced glomerular filtration price and immature hepatic function, which make contributions to significantly prolonging the half-life of this drug. The calculi removed from those patients are composed solely of calcium oxalate. 

  • Laxatives 

Ammonium acid urate calculi are common amongst sufferers with continual diarrhea and have been especially associated with laxative abuse. For these calculi to shape, urine should be supersaturated with both ammonia and uric acid. Ammonia is excreted via the proximal tubule as a method to get rid of nonvolatile acid. An excess ammonia-ion formation may be visible with hunger, dehydration, or consumption of acid-forming meals or toxins. Uric acid solubility is dependent on urine pH: At a pH under the pKa of uric acid, all of the solutes will be in the shape of undissociated acid. Because the pH rises, an increasing share will be in the monohydrogen shape. In maximum urine, this shape may be determined because of the sodium salt, but it could also integrate with ammonium if an excess of this ion is present. Sufferers with chronic diarrhea frequently have low urine volumes and acidic pH. Research of patients who form ammonium acid urate stones has confirmed a pattern of mineral excretion that produces marked supersaturation with admixture to ammonium urate.


Ammonium acid urate calculi are radiolucent until combined with calcium. Although they will be unsuitable for natural uric acid stones, they do no longer effortlessly dissolve with urinary alkalinization. It was found that discontinuation of laxatives may additionally lead to correction of the urinary abnormalities. In a patient, a 12-mm stone disappeared following 18 months of elevated fluid intake and cessation of laxatives. Laxative abuse ought to be suspected in patients who form ammonium acid urate stones in the absence of bowel disease or urinary tract infection.

  • Magnesium Trisilicate

Silica is a ubiquitously allotted detail that is eaten up regularly in foods together with veggies, whole grains, seafood, and even ingesting water. Magnesium trisilicate is a medicinal drug that is available without a prescription for the remedy of signs of gastroesophageal reflux disease. Even though nutritional silicate is without difficulty excreted within the urine, the consumption of excessive quantities of magnesium trisilicate can result in silicate stone formation.

  • Indinavir 

An often seen drug-induced stone is composed of the protease inhibitor indinavir, a medicine used for treating immunodeficiency virus infection in humans. Many patients who take this drug develop symptoms and signs of indinavir nephrolithiasis.20 Pure indinavir stones are not detectable with standard radiography or computerized tomography. 

There are instances when many such drugs induce kidney stones. But no way does that mean you should fear medications. All you need to do is consult your doctor and let them prescribe you medications. If you feel symptoms of kidney stones, it is advisable to visit your doctor and get tested. 

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